霍慧君，博士，副教授，硕士研究生导师，邮箱：huohuijun@qau.edu.cn

　　个人履历：

　　2008.09-2012.07，重庆师范大学，理学学士

　　2012.09-2019.07，中国科学院水生生物研究所，理学博士

　　2019.10-2024.05，ylzz总站线路检测，讲师

　　2024.06-至今，ylzz总站线路检测，副教授

　　研究方向：

　　现从事鱼类免疫与病害防控相关研究。以我国重要水产养殖品种——许氏平鲉和鳜为主要研究对象，聚焦抗菌肽、白介素等天然免疫分子在鱼类抗菌反应中的作用展开系统研究，包括：1）从“结构-功能”关系角度出发，剖析抗菌肽的结构规律，并结合生物信息学分析等方法，挖掘鱼类中潜在的、新颖的抗菌效应基因；2）从多角度解析包括抗菌肽、白介素，以及新型抗菌效应基因的抗菌机制，扩展对鱼类先天免疫分子抗菌方式多样性的理解；3）以抗菌基因为核心点展开病原与宿主的互作关系研究，揭示互作新机制，加深对感染与抗感染过程的理解。

　　科研成果：

　　以第一和通讯作者在Aquaculture、Developmental and Comparative Immunology、Fish and Shellfish Immunology、Journal of Ocean University of China等学术刊物发表SCI论文多篇，主持国家自然科学基金和山东省自然科学基金项目。

　　代表成果：

[1] 国家自然科学基金青年科学基金项目，鳜白介素-26的直接抗菌功能及机制研究（32002422），2021.01-2023.12，24万元，主持。

[2] 山东省自然科学基金青年科学基金项目，许氏平鮋piscidin抗菌肽的抗菌功能，抗菌机制及免疫调节作用研究（ZR2020QC212），2021.01-2023.12，15万元，主持。

[3] 山东省高等学校“青创团队”，鱼类抗菌基因挖掘及分子机制研究创新团队（2022KJ313），2023.01-2025.12，主持。

[4] Shan Nan Chen1; Hui Jun Huo1; Yong Jin; Xue Yun Peng; Bo Li; Xiang Yang Wu; Zhi Wei Zhang; Jing Yun Tian; Qian Wang; Nan Li; Lan Hao Liu; Pin Nie*. The infectious haemorrhagic syndrome virus (IHSV) from rice-field eel (Monopterus albus): Isolation, genome sequence, cross-infection and induced-immune response in Chinese perch (Siniperca chuatsi). Aquaculture 2024, 583: 740561.

[5] Hui Jun Huo; Tian Zhen Yang; Qing Zhu; Chao Li*. Characterization of a CD209-Like Lectin in Black Rockfish (Sebastes schlegelii): Structure features and binding activities as a pathogen recognition receptor. Journal of Ocean University of China. 2023. 22(4). 1098-1108.

[6] Hui Jun Huo1; Tian Zhen Yang1; Qing Zhu; Ning Yang; Chao Li*. A basic investigation on evolution of CL-L1 in vertebrates and its bioactivities in black rockfish (Sebastes schlegelii). Aquaculture 2023, 563: 738923.

[7] Tian Zhen Yang; Qing Zhu; Ting Xue; Min Cao; Qiang Fu; Ning Yang; Chao Li*; Hui Jun Huo*. Identification and functional characterization of CL-11 in black rockfish (Sebastes schlegelii). Fish and Shellfish Immunology 2022, 131: 527-536.

[8] Hui Jun Huo; Tian Zhen Yang; Cheng Bin Gao; Min Cao; Ting Xue; Qiang Fu; Chao Li*. Molecular characterization, antibacterial activity and mechanism analyzation of three different piscidins from black rockfish, Sebastes schlegelii. Developmental and Comparative Immunology 2022, 131: 104394.

[9] Chang Ju Zhuang1, Hui Jun Huo1, Ning Yang, Qiang Fu, Ting Xue, Qing Zhu, Bei Bei Wang, Xiao Li Liu, Chao Li*. Characterization of antibacterial activities and the related mechanisms of a β-defensin in turbot (Scophthalmus maximus). Aquaculture 2021, 541: 736839.

[10] Qing Zhu1; Hui Jun Huo1; Qiang Fu; Ning Yang; Ting Xue; Chang Ju Zhuang; Xiao Li Liu; Bei Bei Wang; Bao Feng Su*; Chao Li*. Identification and characterization of a C-type lectin in turbot (Scophthalmus maximus) which functioning as a pattern recognition receptor that binds and agglutinates various bacteria. Fish and Shellfish Immunology. 2021. 115. 104-111.

[11] Hui Jun Huo; Shan Nan Chen; Zubair Ahmed Laghari; Li Li; Jing Hou; Zhen Gan; Lin Huang; Nan Li; Pin Nie*. Specific bioactivity of IL-22 in intestinal cells as revealed by the expression of IL-22RA1 in Mandarin fish, Siniperca chuatsi. Developmental and Comparative Immunology 2021, 121: 104107.

[12] Hui Jun Huo; Shan Nan Chen; Li Li; Zubair Ahmed Laghari; Nan Li; Pin Nie*. Functional characterization of interleukin (IL)-22 and its inhibitor, IL-22 binding protein (IL-22BP) in Mandarin fish, Siniperca chuatsi. Developmental and Comparative Immunology 2019, 97: 88-97.

[13] Hui Jun Huo; Shan Nan Chen; Li Li; Pin Nie*. Functional characterization of IL-10 and its receptor subunits in a perciform fish, the mandarin fish, Siniperca chuatsi. Developmental and Comparative Immunology 2019, 97: 64-75.

　　备注：

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